“The idea is a very mature way of thinking. It’s almost ingrained as a designer: this is how we approach layout. But we’ve tried to make it work on the web by basically inventing a page, like a best fit. We’ve created a page in a medium where there are no edges, there is no page. The web is different. So I’ve thought up three rules, which I think we need to apply to modern web design. It’s a complete reversing of the way of thinking about it.”
via Mark Boulton on layouts and grid systems | Interview | .net magazine.